Investigation of Peptide-Gold Interfaces for Delivery of Nanoparticles in Vivo
of Peptide-Gold Interfaces for Delivery of Nanoparticles in
goal of our work was to use the EMC to characterize gold-silica
synthesized in our lab that would be used in future peptide binding
studies. The main
from our work at the EMC was the successful synthesis of gold-silica
and the characterization of silica-coated iron oxide nanoparticles. The silica-coated iron
oxide particles were
unsuccessfully used to synthesize magnetic nanoshells.
significance of our characterization studies was to improve our
method for creating gold-silica nanoshells with improved shell
greater monodispersity. These
were used in subsequent studies as surface-enhanced Raman scattering
detection of peptide binding to gold surfaces.
We have followed up on this work with further analysis of
gold interface with more in-depth SERS studies.
This work will allow for the development of bifunctional
the delivery of nanoshells to cancerous tumors.
This work has been published in Plasmonics
2 (3), 119-127 (2007).
with the silica-coated iron oxide particles prompted further work into
of cobalt nanoparticles for nanoshell cores which is ongoing.